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A study performed on several skin cell types in vitro revealed that pathogenic C.acnes strains release extracellular vesicles (EVs) with a specific cargo that activates inflammation‑related factors such as IL‑8, IL‑6 and tumor necrosis factor (TNF) [36]

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A 12-week study in Clinical, Cosmetic, and Investigational Dermatology found modest improvements in skin brightness with regular oral glutathione use, not overnight change