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The Emerging Role of Citrulline and Theanine in Health and Disease: A Comprehensive Review - PMC

Of the homozygous mutations most studied, a carrier of the homozygous T677T isoform produces 75% less methyl folate than someone without the mutation, and carriers of the homozygous C1298C isoform produces 17% less methyl folate (Table 1)

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In addition to glutamate excitotoxicity, the release of cytokines such as IL1β [76] or TNF-α, as well as the infiltration of leukocytes through the release of vasoactive endothelial growth factor (VEGF) by astrocytes, contribute to BBB permeability [77,78]