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Similarly, HCT116 cells treated with the pan-Raf kinase inhibitor AZ628 (~100-fold higher than the IC 50 ) also yielded a small percentage of DTPs, amounting to ~0.70% of the starting population ( Figures 1B, D, E )
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Vourloumis’ group explored a large series of weaker zinc binding groups as potential alternatives to, e.g., the zinc binding amide function found in the 3,4-diaminobenzoic acid derivatives 47 and 48 (Tsoukalidou et al., 2019)
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