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Udenafil, an oral phosphodiesterase-5 inhibitor approved for the treatment of erectile dysfunction has been found by a recent double-blind, placebo-controlled phase IIb clinical trial to improve 6-MWD in patients with PAH, especially those with a history of ERA therapy ( TPN171, a new compound that inhibits PDE5 has been found to significantly reduce mPAP in a rat MCT-PAH model
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